The first time I went to Vegas, I don't think we hit the strip at all except to visit attractions. There is a ton to do in Vegas besides gamble and go to shows. Though a lot of it requires a car.
I've driven in Boston, San Francisco, and NYC. Boston is the only place I feared for my life. Continuously.
The key to traffic safety is to drive predictably. So NYC was full of traffic and pedestrians often ignored traffic signals, but you could count on certain behaviors. SF is similar plus the locals are much more polite about things like letting you change lanes than in NYC. Boston was just madness. Continual madness.