The Canadian system is points-based and works best for younger, highly skilled workers. If you're over 40 and especially if you're over 45, it's very hard to get the points you need to qualify for express entry. Canada and other countries with single payer healthcare generally don't want older or unhealthy people. Cancer and other adverse medical events may disqualify you from immigration entirely. Canada assesses whether you're likely to take more from the system than you'll put in, and will deny you if you're going to be a burden.
Not about Canada, but about emigration in general. I will say as a person who has emigrated:
1) Living abroad is a different experience, even when the language is (mostly) the same. The US-UK expat experience has (or used to have) the highest rate of failure. People move abroad and expect everything to be the same, except it isn't. When I moved to the UK, I had a group of 12 American friends on visas that gave them a path to stay in the UK indefinitely. Only two of us were still here after five years. The culture is entirely different, and there are still days where I feel like I'm an alien.
2) It's even more difficult when you don't speak the language. I toyed with the idea of moving to Italy at a couple of points. When I was there for six months, my language abilities improved, but I've accepted that my fluency is never going to reach a level where I can have deep connections with people. A lot of people on this board who write excellent English have expressed frustration that they can't express themselves as fully in English as in their native language. I never understood it until I tried to actually "live" in Italian. I felt like a 70% version of myself, at best. And that's a language I'm sort of competent with after a lot of effort and study. In France, I feel like the village idiot and have had to call for help in many situations. Restaurants and museums are equipped for tourists. Water and electricity companies, mobile phone and internet providers, etc. are not -- even in major cities. And don't expect a call center to speak English.
3) Being on a visa is no fun. Extra scrutiny. Always in the long queues. Especially in the global political climate, always worried that the rug could be pulled out from under you and your new life could collapse. Times to get permanent residency are starting to get longer and longer. The backlash against immigrants is growing everywhere. Consider how long it would take for you to get permanent residency and assess the risk of the rules changing during that period.
In your case, based on things you have posted, I wonder if relocating somewhere else in the US might be an easier option. Or at least something to try before you leave for another country.
I'm glad I did -- but I'm not sure I'd do it again. Italy closed down the path I used to claim citizenship. The UK is going to lengthen time for permanent residency to 10 years and citizenship to possibly 15. If I had to do it today, signing up to be on a heavily-restricted visa for 10 years.... I'd probably not do it.