Positive C19 Tests

Dobre

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Yeah, I'd think it would be much more likely he still has residual signs of the disease in his system than that he was infected again so briefly after an infection.
 

Sylvia

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"Dutch [tennis] doubles specialist Jean-Julien Rojer (and his partner Wesley Koolhof) are out of the men's doubles in Tokyo after the 39-year-old tested positive for *********. He was due to play mixed w/[Kiki] Bertens, too. Per De Telegraaf." https://twitter.com/OpenCourt/status/1419532079419772928
From the article linked in the tweet: "According to the media reports, Rojer wasn’t staying in the Olympic Village. But he is the fifth person to come up positive from a KLM flight originating in Amsterdam."
 

CantALoop

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Yeah, I'd think it would be much more likely he still has residual signs of the disease in his system than that he was infected again so briefly after an infection.
That's my thought. rRT-PCR (assuming that's what they're doing) is very sensitive, so even a tiny bit of viral RNA can result in a positive result.
I'm not 100% sure a second positive test only a month later means a second infection? Even when you've been testing negative. I don't know how much we know about this.
The numbers vary by study, but this Lancet paper suggests that viral RNA can be detected almost three months post-infection, even though the person may not be actually shedding viable particles: https://doi.org/10.1016/S2666-5247(20)30172-5

Our findings suggest that, although patients with SARS-CoV-2 infection might have prolonged RNA shedding of up to 83 days in upper respiratory tract infection, no live ***** was isolated from culture beyond day 9 of symptoms despite persistently high viral RNA loads.
 

Theatregirl1122

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That's my thought. rRT-PCR (assuming that's what they're doing) is very sensitive, so even a tiny bit of viral RNA can result in a positive result.

The numbers vary by study, but this Lancet paper suggests that viral RNA can be detected almost three months post-infection, even though the person may not be actually shedding viable particles: https://doi.org/10.1016/S2666-5247(20)30172-5

Yeah, I'm aware of that part, although thank you for pulling the link! I just wasn't sure if there was any info on the testing negative in between and what that would mean.
 

Aceon6

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Yeah, I'm aware of that part, although thank you for pulling the link! I just wasn't sure if there was any info on the testing negative in between and what that would mean.
Perhaps the PGA Tour is using a different test, or has an exception for trace loads in players who have had the crud. I’ve been doing some digging around golf sites, but haven’t found anything specific.
 

CantALoop

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Perhaps the PGA Tour is using a different test, or has an exception for trace loads in players who have had the crud. I’ve been doing some digging around golf sites, but haven’t found anything specific.
I had similar questions - what if it’s the testing protocols and methodology? Are they using the same testing methods? Is it one positive test and they’re out?

If someone can be dismissed from one positive test without any follow up testing, it might open up a legal can of worms. At least with HIV testing, a positive test result is always followed up with another test to reduce the chance of false positives.
 

Aceon6

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I had similar questions - what if it’s the testing protocols and methodology? Are they using the same testing methods? Is it one positive test and they’re out?

If someone can be dismissed from one positive test without any follow up testing, it might open up a legal can of worms. At least with HIV testing, a positive test result is always followed up with another test to reduce the chance of false positives.
Golf is two tests, but a player has to go into isolation after the first positive, so it effectively removes you from the current event if your first positive is on a competition day.
 

CantALoop

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Yeah, I'm aware of that part, although thank you for pulling the link! I just wasn't sure if there was any info on the testing negative in between and what that would mean.
I'm thinking either: 1. errors in the testing process itself or 2. (keep in mind, this is conjecture on my part) possible viral latency where the viral genome is still present in a person's cells but lies dormant, and then reemerges later like in shingles. We already know that latency can occur with SARS-CoV-2 in multiple tissues - given the neurological symptoms of *********, I wouldn't be surprised to see multiple papers confirming it.

How/if reactivation occurs and if it could explain testing negative for a time between positive results is probably being researched by multiple labs right now.
 

Sylvia

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Orm Irian

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