I have this issue as I have nieces and nephews with three different brothers and one brother is significantly less wealthy than the others. I put some thought into how I should set up my will and decided that: 1) The fair thing is to allocate it evenly among all the nieces/nephews. 2) I am not going to do the fair thing. Those who need the money the most are going to get it all. I know one of my brothers, in particular, will be mad. But I will be dead so I figure I really dont have to concern myself with it.